ROBINSON1 |
3D Optical Near-field
Ptychography |
Type |
Experimental |
#students |
1 |
Orientation |
Why is
the scientific problem of interest at all? . |
How |
How is
the research going to shed light on the given problem?. The goal
is to determine to Ôoptical volumeÕ filled by each of the 23 different human
chromosomes and compare with probe-based labelling methods, such as M-FISH. |
What |
What is the specific
thing that the student will do, and how does it fit inside the overall
project? This
project will involve setting up a ptychography instrument in a laser lab,
consisting of a small laser, sample XYZ scan stage and a CMOS detector. The ptychography method scans a small
coherent spot over the sample and collects the diffraction pattern. An
algorithm called Òsingle shotÓ PIE is then used to invert the diffraction to
an image. The project will be to
develop a near-field version of the method using lenses to apply a modulated
structure to the scanned probe. If time
permits, the student will then learn how to make chromosome ÔspreadsÕ and
analyse their structure by ptychography. |
Special Knowlegde |
Note:
this project is not based on UCL campus. The experiments will take place at Harwell (near Oxford)
requiring significant time spent travelling |
Supervisor |
Prof Ian Robinson i.robinson@ucl.ac.uk |